Tacrolimus DoseTAIlor

Below is the model for predicting tacrolimus levels or doses, as described in our paper. The minimum required features for a prediction are marked with an asterisk (*), while other features are optional but contribute to improved model performance. Concomitant drugs additional information can be found in CYP3A4/5 information and P-gp infomation .

Prediction Options:

1. Predict Tacrolimus Level (Given Dose):
- Input the desired dose to predict the corresponding tacrolimus level for the patient.
2. Determine Optimal Dose (Given Target Level):
- Input the target level to receive a dose-level curve along with the recommended optimal dose to achieve the desired therapeutic level.

Demographics

Age *

Gender *

Race *

Weight (kg) *

Height (cm) *

Clinical Setting

Blood test

Creatinine (mg/dL)

Albumin (g/dL)

Bilirubin (mg/dL)

AST (U/L)

ALT (U/L)

Sodium (mEq/L)

Potassium (mEq/L)

Hemoglobin (g/dL)

Hematocrit (%)

Concomitant drugs

P-gp Inhibit

P-gp Induce

CYP3A4/5 Inhibit

CYP3A4/5 Induce

Drug-Specific Parameters

Formulation *

Administration Route *

Doses per 24 hrs *

Level Dose Time Difference (days) *

Treatment Days *

Previous Dose Information

Previous Dose (mg) *

Previous Level (ng/ml) *

Previous Level Time Difference (days) *

Prediction Type

Type

Dose (mg) *

Model Prediction

Current parameters: 0 || Model type: Model Not Available